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混合功能聚合物启用多重复合化学传感器补丁用于可穿戴的上皮层压力分析.

Sanjida Yeasmin¹, Ahasan Ullah¹, Bo Wu¹

¹School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, Oregon 97331, United States.

ACS applied materials & interfaces

|October 18, 2023

概括

此摘要是机器生成的。

这项研究引入了一种新型传感器,用于直接测量汗水中的压力激素皮质醇和脱水氨 (DHEA). 这种无标签的方法可以快速地在皮肤上评估下丘脑-垂体-上腺轴的功能.

关键词:

上皮层的压力概况电化学传感器是一种电化学传感器.外部无氧化解反应剂的无氧化解反应剂.没有标签的无标签.有分子印记的聚合物.护理点的护理点.类固醇激素类激素类固醇激素的产生

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科学领域:

电化学电化学电化学
生物医学工程生物医学工程
分析化学分析化学
可穿戴式传感器穿戴式传感器

背景情况:

精确评估压力激素水平,如皮质醇和脱腺固醇 (DHEA),对于理解下丘脑-垂体-上腺 (HPA) 轴功能和生理应激反应至关重要.
传统的类固醇激素检测方法往往耗时,需要复杂的程序,依赖于不稳定的生物受体,需要专门的设备,限制了它们在实时监测中的应用.

研究的目的:

开发一种新的,无标签的,无试剂的电压计测定方法,用于直接检测汗水中的皮质醇和DHEA.
创建一个可穿戴的传感系统,用于在皮肤上直接监测压力激素水平的门诊监测.

主要方法:

开发多目标传感器,使用具有氧化还原活性分子印记聚合物 (氧化还原MIPs),具有针对皮质醇和DHEA的特定结合腔.
在聚合物基质中加入一个稳定的电化学氧化还原活性成分 (聚乙烯),使得在取目标荷尔蒙时能够进行敏感的电流变化.
将开发的氧化还原MIP传感器集成到无线可穿戴传感系统中,用于皮肤上汗水分析.

主要成果:

多重传感器实现了对皮质醇和DHEA的快速检测 (在5分钟内),检测极限低 (分别为115 pM和390 pM).
通过使用集成可穿戴传感系统,成功地在皮肤上的汗水中检测出皮质醇和DHEA.
该试验提供了一种可靠和快速的方法来确定皮质醇-DHEA比率,为HPA轴提供了洞察力.

结论:

一个基于氧化还原MIPs的新型电压计传感平台能够直接,无标签,无试剂检测出汗皮质醇和DHEA.
开发的可穿戴传感系统可以实时在皮肤上监测关键的压力激素,克服传统方法的局限性.
这项技术在对生理应激和HPA轴状态的临床评估方面具有显著的前景.