在真实世界的数据中探索乳腺癌系统性药物治疗模式
Julia O'Rourke1, Jeff Warnick1, John Doole1
1TriNetX, LLC, Cambridge, MA.
JCO clinical cancer informatics
|October 18, 2023
概括
现实世界乳腺癌治疗显示了与NCCN指导方针一致的常见药物治疗模式,但在临床实践中使用的药物管理和循环中存在一些变化.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 医疗信息学 医疗信息学
背景情况:
- 乳腺癌的治疗涉及复杂的药物治疗方案.
- 了解现实世界药物管理对于优化患者护理至关重要.
- 治疗模式的变化可能会影响疗效和患者的结果.
研究的目的:
- 分析乳腺癌患者在现实世界中的药物使用和服药模式.
- 将观察到的治疗方案与既定的临床指南进行比较.
- 识别常见的药物给药序列及其变异.
主要方法:
- 来自TriNetX网络 (2013-2022) 的非识别患者数据的回顾性分析.
- 利用基于规则和无监督学习 (k-means集群) 来提取药物数据和药物使用模式.
- 根据癌症阶段 (早期或晚期) 和受体状态 (HR+/ERBB2-, ERBB2+,TN) 分类患者进行分析.
- 与国家综合癌症网络 (NCCN) 的指导方针进行比较.
主要成果:
- 针对早期HR+/ERBB2-和TN乳腺癌的常见治疗方案包括环胺/多克塞尔和环胺/多克索鲁比辛,其次是帕克利塔塞尔.
- 对于早期的ERBB2+/HR±乳腺癌,经常使用碳白/多克塔克塞尔与特拉斯图祖马布和潜在的珀图祖马布.
- 在7,798名患者中,观察到的药物使用,注射次数和周期长度通常与NCCN建议保持一致.
结论:
- 在现实世界中,乳腺癌药物管理通常与NCCN指南保持一致.
- 在临床实践中,在特定的药物选择和剂量表中存在变化.
- 进一步的研究可以探索这种变异性对治疗结果的影响.
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