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发现基胺衍生物作为抗缺血性中风的强大神经保护剂

Weilin Chen1, Bo Jiang2, Yifan Zhao2

  • 1Key Laboratory of Cardiovascular & Cerebrovascular Medicine, Drug Target and Drug Discovery Center, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China; Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.

European journal of medicinal chemistry
|October 18, 2023
PubMed
概括

研究人员开发了一种新型化合物 (LY836),它抑制了对中风引起的神经元损伤至关重要的蛋白质相互作用. 这种化合物显示出作为治疗缺血性中风的神经保护剂的前景.

关键词:
基二胺的衍生品 基二胺的衍生品具有类似于药物的特性.缺血性中风是因为缺血性中风.神经保护剂是一种神经保护剂.PSD95-nNOS PPI PPI PPI PPI PPI PPI PPI PPI PPI PPI PPI PPI PP

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
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