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Updated: Jul 13, 2025

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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
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软组织和骨的肌皮细胞癌
Hisaki Aiba1, Costantino Errani2, Giovanni Ciani3
1Department of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; Department of Orthopaedic Surgery, Nagoya City University, Nagoya, Japan.
概括
软组织和骨肌皮性癌 (MC-SB) 的复发率很高. 虽然局部疾病的预后更好,但转移性MC-SB尽管接受化疗,但结果不佳,需要多学科专家的护理.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 肌皮细胞癌 (MC) 主要影响唾液腺,但很少发生在软组织或骨中.
- 软组织和骨肌皮性癌 (MC-SB) 是一种罕见的恶性瘤,对最佳治疗策略的了解有限.
研究的目的:
- 评估外科边缘,放射治疗和化疗对MC-SB患者的治疗结果的影响.
- 分析一组MC-SB患者的治疗模式和生存率.
主要方法:
- 对1998年至2015年期间被诊断患有MC-SB的33名患者的医疗记录进行了回顾性分析.
- 对手术切除,辅助放射治疗和化疗方案的评估,以及随访数据.
主要成果:
- MC-SB显示了局部复发的高发病率 (35.7%,幅度很大) 和转移 (24.2%在诊断时).
- 与局部性疾病 (62.6%) 相比,转移性疾病的五年整体存活率明显较低 (12.5%).
- 第一线西斯丁+多克索鲁比辛化疗在5/6名转移患者中产生了客观反应,但平均持续时间很短,为4个月.
结论:
- MC-SB的特点是频繁的局部复发和远程转移,导致预后不佳,特别是在转移病例中.
- 目前的化疗方案为转移性MC-SB提供了有限的长期益处.
- 由于缺乏标准治疗方案,建议在专业中心进行多学科的团队管理.
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