相关实验视频

Updated: Jul 13, 2025

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

9.6K

在Nt17中的电荷调节亨廷聚合和初始脂质结合事件

Alyssa R Stonebraker1, Rachel Hankin1, Kathryn L Kapp1

  • 1The C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Morgantown, WV 26506, USA.

Biophysical chemistry
|October 18, 2023
PubMed
概括

亨廷丁蛋白中N端17氨基酸 (Nt17) 的翻译后修改影响其聚合和脂质结合,可能影响亨廷顿病的病理学. 这些修改改变了蛋白质相互作用,影响了有毒细胞聚合和膜相互作用.

关键词:
粉样蛋白是什么 粉样蛋白是什么原子力显微镜的原子力显微镜.亨廷顿病就是亨廷顿病.质谱测量质量谱测量后翻译修改后的修改.

更多相关视频

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System10:52

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Published on: December 10, 2021

2.6K
Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy11:22

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

Published on: June 27, 2018

8.0K

相关概念视频

Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
3.1K