在翻译研究中,激酶抑制剂的过度度阻碍了有效的药物重定向

Chuan Liu1, Scott M Leighow2, Kyle McIlroy2

  • 1Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA; Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

Cell reports. Medicine
|October 18, 2023
PubMed
概括

通过测量有效的药物暴露,可以改善药物重新定位. 这一新指标预测了白血病和固体瘤中酶抑制剂的临床成功,减少了晚期试验失败.

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