一个韩国家庭的RHD*DNT只有在抗D免疫接种后才能检测到
Dong Woo Shin1, Gun-Hyuk Lee2, Hanah Kim2
1Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
American journal of clinical pathology
|October 18, 2023
概括
识别DNT (一种罕见的部分D变体) 是一个挑战. 这项研究发现DNT个体在血清学上无法与D+区分开来,因此需要RHD基因定型来管理和预防与免疫接种.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- DNT是一种罕见的部分D变体,具有诊断挑战.
- 使用标准的血清学方法很难区分DNT和D+.
研究的目的:
- 为了在一个家庭中识别DNT个体.
- 描述DNT的血清学和临床特征.
- 建议DNT的管理策略.
主要方法:
- 招募韩国第一个DNT试验的家庭成员.
- 在RHD基因定型.
- 使用多种抗D试剂进行弱D测试.
主要成果:
- 在6名家庭成员中发现了3名DNT个体.
- 一个DNT个体开发了一个抗-D alloantibody.
- DNT红细胞与所有抗D克隆具有强烈的反应性,模仿D+.
- 在DNT中出现的独特的血清学发现发生在免疫接种后.
结论:
- DNT个体应接受Rh免疫球蛋白预防和D-血液成分.
- 建议对部分D家族成员进行预期的RHD基因型鉴定,以防止与免疫接种.
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