在不同的反应条件下和各种酸中使用birnessite研究四环素的不同转化
Hang Vo-Minh Nguyen1, Doo-Hee Lee2, Han-Saem Lee3
1Department of Environment Energy Engineering, Seoul National University of Science & Technology, 232 Gongneung-ro, Seoul, 01811, South Korea.
Environmental pollution (Barking, Essex : 1987)
|October 18, 2023
概括
氧化物转化为四环素,其去除效率因pH值和酸存在而有所不同. 这项研究详细介绍了转化途径和产品,在特定条件下确定了降低毒性.
科学领域:
- 环境化学环境化学
- 水处理技术水处理技术
- 氧化过程 氧化过程
背景情况:
- 环素是一种广泛使用的抗生素,具有环境持久性.
- 众所周知,氧化物,特别是石 (δ-MnO2),有助于污染物降解.
- 了解四环素转化动力学和途径对于有效的补救至关重要.
研究的目的:
- 为了研究四环素降解由birnessite (δ-MnO2) 的动力学和转化途径.
- 为了评估pH和奥德里希酸 (ADHA) 对四环素去除效率的影响.
- 识别四环素转化产物并评估它们的毒性影响.
主要方法:
- 实验在pH值为3,6和9进行,有或没有ADHA.
- 使用伪二次反应建模了环素去除动力学.
- 用液体染色学-质谱法/质谱法 (LC-MS/MS) 确定了转化产品.
主要成果:
- 在所有测试条件下,四环素的去除遵循伪二次动力学.
- 清除效率在pH3时最高,随着pH的增加而下降,并受ADHA存在的影响.
- 确定了五种主要的转化产品,pH值为3的ADHA降低了具有较高毒性产品,并增强了具有较低毒性产品.
- 富含O-基团的酸在pH 6时提高了去除效率.
结论:
- 伯尼西特有效地转化四环素,其动力学和效率取决于pH值和湿酸成分.
- 酸的存在可以改变四环素转化产品的毒性概况.
- 这项研究提供了对 δ-MnO2 介导的四环素转化途径的全面见解,为环境修复策略提供了信息.
更多相关视频
08:12Inducing Hairy Roots by Agrobacterium rhizogenes-Mediated Transformation in Tartary Buckwheat Fagopyrum tataricum
Published on: March 11, 2020
12.0K
09:09A Facile Synthetic Method to Obtain Bismuth Oxyiodide Microspheres Highly Functional for the Photocatalytic Processes of Water Depuration
Published on: March 29, 2019
7.8K
相关概念视频
01:15Phase I Reactions: Hydrolytic Reactions
141
Hydrolysis, a cornerstone of phase I biotransformation reactions, uses water to cleave chemical bonds. This process is pivotal in drug metabolism, generating more polar metabolites that can be easily excreted.
An important hydrolytic reaction is ester hydrolysis. Ester bonds, often found in prodrugs, are broken down, increasing the solubility of drugs like aspirin and lidocaine for more straightforward elimination. Amide hydrolysis is another critical reaction, targeting amide bonds prevalent...
An important hydrolytic reaction is ester hydrolysis. Ester bonds, often found in prodrugs, are broken down, increasing the solubility of drugs like aspirin and lidocaine for more straightforward elimination. Amide hydrolysis is another critical reaction, targeting amide bonds prevalent...
141
01:19Phase II Reactions: Miscellaneous Conjugation Reactions
64
Phase II biotransformations are detoxification mechanisms that conjugate xenobiotics with endogenous substances, neutralizing their toxicity.
A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
64
01:26Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride
1.8K
Radical substitution reactions can be used to remove functional groups from molecules. The hydrogenolysis of alkyl halides is one such reaction, where the weak Sn–H bond in tributyltin hydride reacts with alkyl halides to form alkanes. Here, the reagent Bu3SnH yields tributyltin halide as a byproduct.
The bonds formed in this reaction are stronger than the bonds broken, making it energetically favorable. The reaction follows a radical chain mechanism similar to radical halogenation...
The bonds formed in this reaction are stronger than the bonds broken, making it energetically favorable. The reaction follows a radical chain mechanism similar to radical halogenation...
1.8K
01:26Transformation
15
Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
15
01:16Drug Biotransformation: Overview
2.4K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
2.4K
01:23Amines to Sulfonamides: The Hinsberg Test
3.6K
The Hinsberg test is a method to identify primary, secondary and tertiary amines, named after its pioneer, Oscar Hinsberg. Here, amines are treated with benzenesulfonyl chloride, also known as the Hinsberg reagent, in the presence of an excess of aqueous base, followed by acidification. Based on the nature of the amines, different changes are observed.
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing...
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing...
3.6K