在蛋白尿性腎病症中,Ganoderma lucidum 多糖抑制了腎內PRR-RAS通路
Hui Fang1, Xinxuan Li1, Dongmei Lin2
1Key Laboratory of Applied Pharmacology in Universities of Shandong, Department of Pharmacology, School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
International journal of biological macromolecules
|October 18, 2023
概括
光的化合物GL-PP和GL-PP2可以防止蛋白尿引起的损伤. GL-PP2显示出优异的抗炎作用和用于治疗病的工业可行性.
科学领域:
- 药理学和病学 药理学和病学
- 自然产品化学 自然产品化学
- 生物化学 生物化学
背景情况:
- 过度的蛋白尿会导致功能障碍和损伤.
- 光的多糖 (GL-PP和GL-PP2) 是具有潜在治疗功能的生物活性化合物.
- 蛋白受体 (PRR) - 蛋白-血管新生素系统 (RAS) 途径与病进展有关.
研究的目的:
- 研究GL-PP和GL-PP2对蛋白尿引起的功能障碍和损伤的保护作用.
- 在临床前模型中比较GL-PP和GL-PP2的疗效和机制.
- 评估GL-PP2.2的药理和工业潜力.
主要方法:
- 使用了蛋白尿引起的损伤的老鼠和细胞模型.
- 评估损伤,蛋白尿,炎症标志物,氧化应激和纤维化.
- 分析了PRR-RAS通路,环氧化原酶-2和可诱导的氧化合成酶的抑制.
主要成果:
- GL-PP和GL-PP2都减少了损伤,蛋白尿,炎症,氧化应激和纤维化.
- 与GL-PP相比,GL-PP2表现出较强的循环氧化酶-2和可诱导的氧化合成酶抑制.
- 这两种化合物都抑制了PRR-RAS通路,改善了细胞活力,并在细胞模型中表现出抗炎性质.
结论:
- GL-PP和GL-PP2通过调节PRR-RAS通路并减少炎症,显示出对蛋白尿引起的损伤的保护作用.
- GL-PP2由于其优异的抗炎活性和对药理学和工业应用的更大可行性,显示出增强的治疗潜力.
- GL-PP2是治疗蛋白尿引起的病的有希望的候选者,需要进一步的临床研究.
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