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合成和评估F标记的胺胺作为恶性黑色素瘤的PET成像剂

Ayoung Pyo¹, Misun Yun², Boreum Song¹

¹College of Pharmacy and Research Institute of Pharmaceutical Science, Gyeongsang National University, Jinju, Republic of Korea.

Bioorganic & medicinal chemistry letters

|October 18, 2023

概括

一种新型的放射性标记物,-18标记为procainamide (18F-PCA),显示出检测侵略性恶性黑色素瘤的希望. 这种药物向黑色素,使得在临床前模型中直接可视化黑色素瘤瘤.

科学领域:

核医学是一种核医学.
放射化学放射化学是指辐射化学.
在瘤学瘤学.

背景情况:

恶性黑色素瘤是一种具有高死亡率的侵袭性皮肤癌.
有效的诊断工具对于早期发现黑色素瘤至关重要.

研究的目的:

为了合成和评估18F标记的普罗卡因胺 (18F-PCA) 作为黑色素瘤的PET成像剂.
评估18F-PCA的生物特征和诊断潜力.

主要方法:

合成18F-PCA并评估放射化学产量和体外稳定性.
在l-tyrosine的存在和缺席下对细胞吸收的评估.
在小型动物模型中对黑色素瘤异种移植的体内微PET成像.

主要成果:

18F-PCA在体外表现出良好的稳定性和10-15%的放射性化学产量.
18F-PCA的细胞吸收被l-tyrosine显著增强.
在体内研究表明,成功可视化黑色素瘤外移植,具有高瘤-肝脏吸收率和初级病变的特定吸收率.

结论:

18F-PCA表现出高的黑色素向能力.
18F-PCA显示出作为PET成像剂直接检测黑色素瘤的潜力.

关键词:

(18) F标签的使用.恶性黑色素瘤是一种恶性黑色素瘤.分子成像学分子成像学定子发射断层扫描 (PET) 是一种定子发射断层扫描.普罗卡因胺是什么普罗卡因胺是什么

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