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在MINOCA之后,患有复发性急性心肌梗塞的患者的特征
Giuseppe Ciliberti1, Federico Guerra1, Carmine Pizzi2
1Cardiology and Arrhythmology Clinic, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.
Progress in cardiovascular diseases
|October 18, 2023
概括
心肌梗塞与非阻塞冠状动脉 (MINOCA) 患者经历反复事件经常显示动脉样硬化进展. 许多人没有达到推的胆固醇水平,这表明低估了心血管疾病风险.
科学领域:
- 心脏病学 心脏病学
- 心血管研究研究心血管研究
- 内部医学 内部医学
背景情况:
- 带有非阻塞冠状动脉的心肌梗塞 (MINOCA) 是一种具有复杂管理的已知的疾病.
- 复发性急性心肌梗塞 (re-AMI) 在一些MINOCA患者中发生,但预测因素尚不清楚.
研究的目的:
- 在MINOCA患者中确定与重新AMI相关的临床和血管学因素.
- 评估 MINOCA 患者中冠状动脉样硬化和心血管疾病 (CVD) 风险的进展,这些患者经历了再次的AMI.
主要方法:
- 对MINOCA患者进行的回顾性多中心队列研究.
- 在MINOCA患者与没有重新AMI患者之间的特征比较.
- 对第一次和重复的侵入性冠状动脉血管学 (ICA) 发现的分析,包括动脉样硬化进展和再血管化.
主要成果:
- 在初始ICA时,MINOCA重复AMI患者的冠心病发作频率较低,多血管/左主干动脉样硬化率较高.
- 在接受重复ICA的重复AMI患者中,近一半的患者表现出动脉样硬化进展,41.7%患有阻塞性疾病.
- 只有4.5%的人达到目标LDL-C水平 (<55 mg/dL),33%的人经历了随后的心血管疾病事件.
结论:
- 少数MINOCA重复AMI患者经历了重复ICA,但近一半的动脉样硬化进展往往需要重新血管化.
- 低于最佳水平达到推的LDL-C水平凸显了这一群体对心血管疾病风险的潜在低估.
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