关于在德国南部的一所高等大学中心出现一种新的抗万科素的Enterococcus faecium菌株ST1299/CT1903/vanA
A Rath1, B Kieninger1, A Caplunik-Pratsch1
1Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.
The Journal of hospital infection
|October 18, 2023
概括
2020年出现了一种新的VanA阳性VREfm克隆,ST1299/CT1903,导致率增加. 全基因组测序揭示了它的高克隆性,并在医院内传播.
科学领域:
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 携带vanB,特别是序列类型 (ST) 80和ST117的抗万科菌 Enterococcus faecium (VREfm) 之前在德国占主导地位.
- 在2020年,我们医院观察到VanA阳性VREfm的显著增加.
研究的目的:
- 在医院环境中调查VREfm传播的动态.
- 为了确定VREfm菌株的遗传特征和流行病学联系.
主要方法:
- 来自2020年接受治疗的患者的VREfm分离物的回顾性分析.
- 使用了vanA/vanB PCR,全基因组测序 (WGS),多位置测序类型 (MLST) 和核心基因组 (cg) MLST.
- 使用医院占用数据评估流行病学联系.
主要成果:
- 319个VREfm分离物的全基因组测序揭示了高克隆性,其中有三个主要的序列类型 (ST) 和复杂类型 (CT).
- 一种新的新兴菌株ST1299 (100%的vanA,77.4%的CT1903) 显示出显著的传播潜力.
- 在56.7%的病例中证实了鼻腔传染,共用房间和部门被确定为关键的流行病学联系.
结论:
- ST1299/CT1903/vanA克隆的出现是2020年该机构VREfm费率增加的主要驱动因素.
- 这项研究强调了WGS在跟踪和了解VREfm流行病学的重要性.
- 有效的感染控制措施对于缓解高克隆性VREfm菌株的传播至关重要.
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