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美国50岁以上人口中的血三甲度和骨关节炎

Yang Sun^1,2,3, Yi-Xin Wang⁴, Dongyang Qian^5,6

¹Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Environmental science & technology

|October 18, 2023

概括

暴露于三甲基 (Br-THM) 可能会增加老年人骨关节炎的风险. 较高的血液Br-THM水平与氧化应激标志物和患关节炎的可能性更高有关.

科学领域:

环境健康环境健康
流行病学流行病学
毒理学毒理学毒理学

背景情况:

三甲 (THM) 是饮用水中的消毒副产品.
暴露于THM与炎症和氧化应激有关.
骨关节炎 (OA) 的发病包括炎症和氧化应激.

研究的目的:

调查50岁以上美国成年人血液THM度和骨关节炎之间的关联.
探索THM暴露和氧化应激标志物之间的关系.

主要方法:

来自七个国家健康和营养检查调查 (NHANES) 周期 (1999-2012) 的数据.
包括4077名年龄在50岁以上的成年人,血中THM水平量化 (TCM,BDCM,DBCM,TBM).
使用后勤回归来评估OA的几率和与氧化应激标志物 (-胺转移酶) 的剂量反应关系.

主要成果:

随着血中二甲 (BDCM),二甲 (DBCM) 和总化THM (Br-THM) 度较高,观察到骨关节炎的几率增加.
在BDCM,DBCM,Br-THM水平和氧化应激的标志物血清玛-胺转移酶之间发现了积极的剂量反应关系.
较高的血液Br-THM度与高马-氨基转移酶和增加骨关节炎风险有关.

结论:

血中三甲基 (Br-THM) 度与50岁以上美国成年人骨关节炎风险增加有关.
通过氧化应激途径,THM暴露可能导致骨关节炎的发展.
需要进一步的前性研究来证实这些发现并阐明机制.

关键词:

消毒副产品的消毒方法饮用水饮用水饮用水这是一种炎症炎症炎症炎症.骨关节炎是一种关节炎.氧化应激是一种氧化应激.公共卫生公共卫生.三甲三甲是一种三甲.

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