结直肠癌诊断生物标志物:除了便中的血红蛋白
A Krishnamoorthy1, R Arasaradnam1
1Warwick Medical School, Gibbet Hill Campus, University of Warwick, Coventry, CV4 7AL, UK.
Best practice & research. Clinical gastroenterology
|October 18, 2023
概括
结肠直肠癌 (CRC) 诊断对于预后至关重要. 本综述审查了现有和新兴的诊断生物标志物,超出便免疫化学测试,以改善早期检测和预测CRC的治疗反应.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 生物标志物研究 生物标志物研究
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 癌症在诊断时的阶段显著影响预后和生存率.
- 针对性疗法和免疫疗法的进展正在改善CRC患者的治疗结果.
研究的目的:
- 审查各种结直肠癌诊断生物标志物背后的证据.
- 讨论这些生物标志物的当前临床应用.
- 探索新型CRC生物标志物的潜在未来用途.
主要方法:
- 关于结直肠癌生物标志物的现有研究的文献综述.
- 对已批准和正在研究的诊断标记物的分析.
- 评估生物标志物的性能,以早期检测和治疗反应.
主要成果:
- 便免疫化学检测血红蛋白是广泛使用的CRC生物标志物.
- 其他几种生物标志物已获得批准或处于临床验证阶段.
- 生物标志物对于早期检测和预测对治疗的反应至关重要.
结论:
- 诊断生物标志物对于改善结直肠癌结果至关重要.
- 对于新出现的生物标志物,需要进一步的研究和验证.
- 生物标志物对个性化CRC管理具有重大潜力.
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