吉兰-巴雷综合征与COVID-19感染和接种疫苗之间的关联:基于人口的嵌套病例控制研究
Haya Bishara1, Anat Arbel2, Ofra Barnett-Griness1
1From the Department of Neurology (H.B., S.B.), and Department of Internal Medicine B (A.A., S.C.), Lady Davis Carmel Medical Center; Ruth and Bruce Rappaport Faculty of Medicine (A.A., S.B., S.C., R.N.-D., N.G., W.S.), Technion-Israel Institute of Technology; Statistical Unit (O.B.-G., W.S.), Department of Community Medicine and Epidemiology (O.B.-G., N.G.), and Infection Control and Prevention Unit (R.N.-D.), Lady Davis Carmel Medical Center, Haifa; Sackler Faculty of Medicine (E.A.), Tel Aviv University; Department of Neurology (E.A.), Rabin Medical Center, Petach Tikva; and Translational Epidemiology Unit and Research Authority (W.S.), Lady Davis Carmel Medical Center, Haifa, Israel.
严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染增加了吉兰-巴雷综合征 (GBS) 的风险,而瑞-生物科技的COVID-19疫苗似乎降低了GBS风险. 需要进一步的研究来证实这些发现.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 关于吉兰-巴雷综合征 (GBS) 在COVID-19感染和接种疫苗后发生的不确定的数据存在.
- 评估GBS与严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染和COVID-19疫苗接种之间的关联至关重要.
研究的目的:
- 评估GBS和SARS-CoV-2感染之间的关联.
- 为了确定GBS和COVID-19疫苗接种之间的关联.
主要方法:
- 在3,193,951名年龄在16岁以上且未先前诊断出GBS的患者中进行了嵌套病例对照研究.
- 根据年龄和性别,GBS病例与10个对照病例进行了匹配.
- 评估了在前6周内接触SARS-CoV-2感染和COVID-19疫苗接种的情况.
主要成果:
- 发现GBS与SARS-CoV-2感染相关的几率比率显著增加 (OR 6.30).
- 与瑞-生物科技COVID-19疫苗 (OR 0.41) 相关的是GBS的几率比率显著下降.
- 在不同暴露确定窗口 (4周和8周) 中,结果保持一致.
结论:
- 感染SARS-CoV-2与患有GBS的风险增加有关.
- 瑞-生物科技COVID-19疫苗可能与降低GBS风险有关.
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