慢性炎症疾病增加后血栓形成综合征的风险:一项前性队列研究
Aaron F J Iding1, Thibaut M P Limpens2, Hugo Ten Cate3
1Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; Thrombosis Expertise Center, Heart+Vascular Center, Maastricht University Medical Center, Maastricht, The Netherlands.
European journal of internal medicine
|October 18, 2023
概括
患有慢性炎症性疾病 (CID) 的患者在深静脉血栓症 (DVT) 后,患有后血栓症综合征 (PTS) 的风险更高. 未经治疗的CID进一步增加了这种风险,可能是由于残留的静脉阻塞.
科学领域:
- 血管医学 血管医学
- 炎症性疾病 炎症性疾病
- 血栓形成研究研究
背景情况:
- 深静脉血栓症 (DVT) 管理侧重于预防复发性静脉血栓栓塞 (VTE) 和血栓后综合征 (PTS).
- 慢性炎症性疾病 (CID) 是复发性VTE的已知危险因素,但其对PTS的影响还未得到充分研究.
研究的目的:
- 评估患有CID的患者中PTS的风险.
- 评估抗炎治疗对这一队列中PTS风险的影响.
主要方法:
- 对801名近端DVT患者 (不包括活跃癌症) 进行两年的前性随访.
- CID的分类包括炎症性肠病,风湿性疾病和痛风.
- 通过超声波评估残留静脉阻塞 (RVO);使用维拉拉塔得分诊断PTS.
主要成果:
- 10.2%的患者患有持续性心脏病. 在患有CID (35.4%) 的患者中,PTS的发病频率高于没有CID的患者 (18.9%).
- RVO患病率在各组之间相似,但在CID患者中与PTS有很强的关联.
- 未经治疗的CID与更高的RVO率和PTS风险增加有关 (HR 2.18).
结论:
- 患有CID的患者在DVT后面临PTS的风险增加.
- 缺乏抗炎治疗会加剧PTS风险,可能通过恶化RVO和静脉病理.
相关概念视频
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
12
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
12
Venous Thrombosis I: Introduction
11
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
11
Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
Peripheral Artery Disease V: Postoperative Nursing Management
12
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
12
Anticoagulant Drugs: Low-Molecular-Weight Heparins
723
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
723
Peripheral Artery Disease I: Introduction
9
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
9


