系统性血压与大脑皮质结构的异常变化有关:来自孟德尔随机化研究的证据
Ziliang Ye1, Qing Zeng1, Limeng Ning1
1Department of Cardiology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, No. 85 Hedi Road, Nanning, Guangxi 530021, China.
European journal of internal medicine
|October 18, 2023
概括
系统性血压,而不是其他措施,与大脑皮层表面积的减少有关. 这项孟德尔的随机化研究澄清了血压.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 心血管科学 心血管科学
背景情况:
- 高血压是脑血管疾病和认知能力下降的已知危险因素.
- 各种血压成分对大脑结构的精确影响尚未完全理解.
- 门德尔随机化 (MR) 提供了一个强大的方法来探索血压和大脑变化之间的因果关系.
研究的目的:
- 为了研究不同血压成分和大脑皮层结构之间的因果关系.
- 为了确定抽缩血压,腹缩血压,脉冲压 (PP) 或平均动脉压 (MAP) 是否影响大脑皮层表面积和厚度.
主要方法:
- 利用大规模的全基因组关联研究 (GWAS) 来获得血压和神经成像数据.
- 采用孟德尔随机化 (MR) 方法,对高血压,静缩血压,透缩血压,PP和MAP的遗传变异进行研究.
- 在大队伍中对大脑皮层表面积和皮层厚度的评估影响.
主要成果:
- 缩血压与大脑皮层表面积的减少有显著的关联 (β=-1330.69,p=0.0489).
- 在缩血压和大脑皮层厚度 (p=0.1287) 之间没有发现显著的关系.
- 高血压,透气血压,PP和MAP并没有与大脑皮层表面积或厚度显著相关.
结论:
- 系统性血压与大脑皮质结构的异常变化有关,特别是表面积的减少.
- 根据这项MR分析,其他血压成分,如透气血压,PP和MAP似乎对大脑皮质结构没有显著影响.
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