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Updated: Jul 13, 2025

Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs
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Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs

Published on: June 1, 2018

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哺乳动物 tympanic 膜中的表观再生

Sonia M Scaria1, Stacey M Frumm1, Ellee P Vikram1

  • 1Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, 94143, USA.

NPJ Regenerative medicine
|October 18, 2023
PubMed
概括

成年哺乳动物的耳膜 (TM) 可以再生复杂的组织,与典型的基于痕的伤口愈合不同. 这一发现揭示了TM作为哺乳动物再生的模型,挑战了以前的信念.

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In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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