双相情感障碍的多基因风险与青少年灰质结构和白质完整性的关联
Xinyue Jiang1,2, Clement C Zai3,4, Kody G Kennedy1
1Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Translational psychiatry
|October 18, 2023
概括
这项研究发现,双极性障碍 (BD-PRS) 的多基因风险评分与年轻人灰质和白质完整性的减少有关. 这表明BD-PRS可能表明神经生物学的脆弱性发展双相情感障碍.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 青少年双极性障碍 (BD) 呈现出大脑异常,但其多基因基础仍然不清楚.
- 了解BD神经发育轨迹的遗传贡献对于早期识别和干预至关重要.
研究的目的:
- 在患有BD和没有BD的青少年中,研究BD多基因风险评分 (BD-PRS) 与大脑结构 (灰质) 和完整性 (白质) 之间的关联.
- 探索成年人衍生的遗传风险得分是否可以识别青年的神经成像脆弱性标志物.
主要方法:
- 利用了113名青少年的T1加权和扩散加权MRI扫描 (66名BD,44名健康对照[HC]).
- 使用PRS-CS-auto计算BD-PRS,基于成人全基因组总结统计数据.
- 进行了顶点和声量分析,以将BD-PRS与灰色物质指标 (皮质体积,表面积,厚度) 和分数异构 (FA) 相关联.
主要成果:
- 在组合样本中,较高的BD-PRS与额头和部区域较小的灰质体积相关.
- 在BD组中,较高的BD-PRS与前额,部和状区域的皮质厚度降低有关.
- 较高的BD-PRS与年轻人广泛分布的白质区域中较低的微分异性相关.
结论:
- 来自成人数据的双极性障碍多基因风险评分与年轻人的结构和微观结构大脑差异有关.
- 这些发现表明,BD-PRS可能作为青少年患双极性障碍易受伤害的神经成像标志物.
- 建议进行纵向研究,以证实预测价值,并探索与疾病过程和治疗的相互作用.
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