短链脂肪酸,丁酸盐可以防止吗啡和帕克利塔塞尔诱导的感觉过敏
Dawn Jessup1, Kareem Woods1, Sach Thakker1
1Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298, USA.
Scientific reports
|October 18, 2023
概括
口服酸盐 (NaBut) 补充剂可以逆转吗啡和帕克利塔塞尔引起的疼痛过敏. 这种短链脂肪酸 (SCFA) 防止与这些常见药物治疗相关的疼痛敏感性和神经元过敏性增加.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 慢性阿片类药物和化疗使用可能导致严重的疼痛过敏,影响患者的生活质量.
- 类阿片类药物诱导过敏症 (OIH) 和化疗诱导过敏症 (CIH) 的特点是对疼痛刺激的敏感性增加.
- 潜在的机制,特别是肠道衍生媒介的作用,尚未完全理解.
研究的目的:
- 调查短链脂肪酸 (SCFA) 酸 (NaBut) 在逆转OIH和CIH方面的潜力.
- 探索肠道衍生媒介在药物诱导的可感性过敏症中的参与.
- 为了确定NaBut是否调节与OIH和CIH相关的神经元过刺激性.
主要方法:
- 鼠标行为模型被用来评估热性过敏症 (OIH) 和冷性全音症 (CIH).
- 进行了背部根结质 (DRG) 神经元的电生理记录,以测量神经元刺激性.
- 实验涉及口服NaBut和使用结肠条件介质来评估肠介质效应.
主要成果:
- 口服NaBut治疗在接受过吗啡治疗的小鼠中预防了热性过敏症,在接受过帕克利塔塞尔治疗的小鼠中预防了寒冷的体症.
- 使用NaBut可以逆转用吗啡或帕克利塔塞尔治疗小鼠的DRG神经元中神经元过敏度的增加.
- 接受过吗啡治疗的小鼠的肠道条件介质诱导了DRG神经元的过度兴奋,这种效果被NaBut联合治疗所阻碍.
结论:
- 短链脂肪酸甲酸盐有效地逆转了阿片类药物和化疗引起的疼痛过敏.
- 肠道衍生调解剂在调解药物诱导的神经元过敏症方面发挥着重要作用.
- NaBut的治疗效果似乎是间接的,这表明它调节了来自肠道的信号,而不是直接作用于神经元.
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