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Updated: Jul 13, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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通过ATP和SAM的结合进行抗病毒III型CRISPR信号传递

Haotian Chi1, Ville Hoikkala1,2, Sabine Grüschow1

  • 1Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews, UK.

Nature
|October 18, 2023
PubMed
概括

在 Bacteroides fragilis 中的 III-B CRISPR 系统使用 S- 腺胺-AMP (SAM-AMP) 来进行抗病毒防御,而不是循环胺酸盐. 这种新型的第二信使准了膜蛋白,

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