在韩国的儿科视神经炎后,出现中枢神经系统脱髓化攻击或视神经炎复发的风险
Yeji Moon1, Kyung-Ah Park2, Jinu Han3
1Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
概括
儿童视神经炎 (ON) 患者具有特定的MRI发现,面临随后中枢神经系统 (CNS) 脱髓化攻击的更高风险. 早期的多学科评估有助于预测这些未来事件.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 视神经炎 (ON) 是一种影响视神经的脱髓化疾病.
- 儿科ON可以是中枢神经系统 (CNS) 脱髓化疾病的初始表现.
- 识别疾病进展的风险因素对于早期干预至关重要.
研究的目的:
- 在韩国儿童中确定中枢神经系统脱髓化发作和首次ON发作后ON复发的比率.
- 确定与儿科ON患者疾病进展相关的风险因素.
主要方法:
- 一项多中心的回顾性队列研究,对132名儿科ON患者进行了多中心的回顾性队列研究,这些患者之前没有中枢神经系统脱髓化.
- 分析临床数据,神经眼科检查,MRI和抗体检测.
- 计算中枢神经系统脱髓化和ON复发的5年累积概率.
主要成果:
- 中枢神经系统脱髓化攻击的5年累积概率为14.0±3.6%.
- 脑外视神经/眼干扰和无症状的MRI病变预测了中枢神经系统的攻击.
- 在5年内,ON复发的累积概率为24.6±4.0%,在AQP4-IgG阳性组 (83.3±15.2%) 显著更高.
结论:
- 脑/脊髓成像和抗体检测对于预测儿科ON的未来脱髓化事件至关重要.
- 建议采用多学科的方法来管理患有中枢神经系统脱髓化风险的儿科ON患者.
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