抗氧化剂丰富的日本饮食与慢性病之间的关联:Ohasama研究
Megumi Tsubota-Utsugi1, Michihiro Satoh2,3, Jun Watanabe4
1Department of Hygiene and Public Health, Teikyo University School of Medicine.
Journal of atherosclerosis and thrombosis
|October 19, 2023
概括
富含脂性抗氧化剂的饮食可能会降低慢性病 (CKD) 的风险,特别是在女性中. 平衡抗氧化剂摄入量与生活方式因素对脏健康至关重要.
科学领域:
- 营养流行病学 营养流行病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生化学
背景情况:
- 饮食中的抗氧化剂,按水友性 (H-) 和脂友性 (L-) 能力分类,可能具有不同的生理效应.
- 富含抗氧化剂的饮食与慢性病 (CKD) 发病率之间的关联仍未得到充分研究.
研究的目的:
- 调查饮食中含有水友性 (H-) 和脂友性 (L-) 抗氧化能力 (AOC) 与一般日本人口中患CKD的风险之间的关联.
主要方法:
- 一组922名没有CKD的个人被跟踪了中位数9.7年.
- 结核病发病率是由蛋白尿和/或估计的球过率 (eGFR) <60毫升/分钟/1.73米2来定义的.
- 饮食H-AOC和L-AOC使用日本食品数据库进行评估,并使用Cox比例危险模型计算危险比率.
主要成果:
- 总共记录了137起CKD事件.
- 在调整了混杂因素后,L-AOC摄入量最高四分位数与女性中CKD风险降低51%显著相关.
- 增加L-AOC摄入量对女性的eGFR降低比蛋白尿更有保护作用;对于男性的H-AOC或L-AOC没有发现显著的关联.
结论:
- 摄入大量的脂类抗氧化剂可能与患CKD的风险降低有关.
- 维持饮食中抗氧化剂摄入量和生活方式引起的亲氧化剂之间的平衡对于预防损伤至关重要.
相关概念视频
01:24Chronic Kidney Disease II: Clinical Manifestations
12
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
12
01:25Chronic Kidney Disease I: Introduction
18
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
18
01:28Chronic Kidney Disease III: Interprofessional Care
21
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
21
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
19
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
19
01:29Renal Regulation of Acid-Base Balance
482
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
482
01:18Chronic Kidney Disease IV: Nursing Management
9
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
9