澄清的复杂化学成分 (II) 使用单晶X射线衍射和光谱技术对可卡因进行基于酸的测试
Raychelle Burks1,2, Lars Öhrström2, Francoise M Amombo Noa2,3
1Department of Chemistry, American University, Washington, District of Columbia, USA.
Journal of forensic sciences
|October 19, 2023
概括
对可卡因的二酸盐测试可能会产生利多卡因的错误阳性. 这项研究对反应产物进行了表征,揭示了不同的离子对和协调复合体,有助于测试优化.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 法医化学 法医化学
背景情况:
- 对于选可卡因而言,二酸盐测试是常见的.
- 利多卡因及其盐在这些测试中已知是假阳性的.
- 未解决的产品结构和反应途径阻碍了测试的改进.
研究的目的:
- 为了澄清 (II) 硫酸与可卡因化物和利多卡因的反应途径和产品结构.
- 为了改善药物查,区分可卡因和利多卡因反应产物.
主要方法:
- 单晶X射线衍射被用来确定晶体结构.
- 使用了包括UV-Vis,ATR-IR和Raman在内的光谱技术.
- 对反应产品进行了元素分析.
主要成果:
- 可卡因化物反应产生了一个无形的蓝色离子对, (可卡因+) 2[Co(SCN) 4) 2-.
- 利多卡因化单水合物反应产生了离子对的针状晶体 (Hlidocaine+) 2[Co(SCN) 4) 2-·H2O.
- 还观察到被称为协调化合物cis-和trans-[CoL2(SCN) 2 (L=利多卡因) 的粉红色晶体和一种协调聚合物trans-[Co(H2O) 2 ((SCN) 2) ·H2O.
结论:
- 这项研究阐明了可卡因和利多卡因与二酸反应形成的独特结构.
- 离子对和协调复合体的表征为优化选试验提供了基础.
- 了解这些反应产物可以帮助减少法医药物分析中的假阳性.
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