成年人暴露于 perfluoroalkyl 物质和高脂血症:来自 NHANES 2017-2018 年的数据
Weilong Xing1, Mengyuan Liang, Wen Gu
1From the Laboratory of Pesticide Environmental Assessment and Pollution Control, Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment (MEE), Nanjing, People's Republic of China.
Journal of occupational and environmental medicine
|October 19, 2023
概括
暴露于 perfluoroalkyl 物质 (PFAS),特别是血清 perfluoromethylheptane 硫酸异构体 (Sm-PFOS),与增加高脂血症风险有关. 需要进一步的研究来证实这一关联.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- perfluoroalkyl物质 (PFAS) 是广泛使用的合成化学品,具有潜在的健康影响.
- 人们越来越担心环境污染物与诸如高脂血症等慢性疾病之间存在关联.
研究的目的:
- 为了研究暴露于各种 perfluoroalkyl 物质 (PFAS) 和高脂血症之间的关系.
- 为此分析,利用国家健康和营养检查调查 (NHANES) 的数据.
主要方法:
- 分析了来自NHANES的1600名受试者的数据.
- 在血清样本中测量了九种不同类型的PFAS.
- 应用多变量逻辑回归来评估血清PFAS水平与高脂血症之间的关联.
主要成果:
- 在血清 perfluoromethylheptane 硫酸异构体 (Sm-PFOS) 和高脂血症之间观察到显著的积极关联.
- 在Sm-PFOS的第三个和最高四分之一的个体中,分别增加了57%和41%的超脂血症的可能性.
- 这种关联在60岁以下的个体中仍然显著,Sm-PFOS最高四分之一的赔率比为1.81.
结论:
- 血清Sm-PFOS独立地与高脂血症的风险增加有关.
- 这些发现表明,Sm-PFOS暴露与高脂血症之间存在潜在的联系.
- 建议进行进一步的流行病学研究,以确定确定的因果关系.
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