超声波诱导的瘤 perfusion 变化和 doxorubicin 输送:对脉冲长度和脉冲重复频率的研究
Luhua Bai1, Tingting Luo1, Jiawei Tang1
1Department of Ultrasound, The Second Affiliated Hospital of Army Medical University, Chongqing, China.
概括
优化超声刺激微气泡 (USMB) 参数,特别是短脉冲长度 (PL) 和高脉冲重复频率 (PRF),显著提高了多克索鲁比 (DOX) 输送到瘤的速度. 这种组合改善了瘤输液和药物度,与较长的PL和较低的PRF不同.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 对瘤的 doxorubicin (DOX) 输送往往受到生理障碍的限制.
- 超声刺激微气泡 (USMB) 疗法提供了一种增强药物输送的潜在方法.
- 优化USMB参数对于有效的治疗结果至关重要.
研究的目的:
- 为了确定脉冲长度 (PL) 和脉冲重复频率 (PRF) 的最佳组合,用于超声刺激微气泡 (USMB) 治疗.
- 为了研究不同USMB参数对多克索鲁比 (DOX) 输送到瘤的影响.
- 探索增强药物输送的潜在机制.
主要方法:
- 携带瘤的小鼠被分为对照组和USMB治疗组.
- 与对比度增强的超声波成像评估了瘤血液输液.
- 光显微镜和HPLC量化了DOX水平.
- 显微镜检查和炎症因子分析阐明了治疗机制.
主要成果:
- 短PL (3周期) 和高PRF (2千赫) 显著增加瘤 perfusion (26.67%) 和DOX度 (4.69x控制).
- 长PL (34.5周期) 和低PRF (200赫兹) 并没有改善DOX输送,并导致微血管损伤.
- 短PL/高PRF促进了血管扩张和增加了血管扩张性炎症因素.
结论:
- 超声刺激微气泡 (USMB) 治疗与短脉冲长度和高脉冲重复频率有效地提高瘤血液输液和多克索鲁比 (DOX) 输送.
- 较长的脉冲长度和较低的脉冲重复频率是无效的,可能导致不良影响.
- 优化USMB参数是提高化疗疗效能的关键.
关键词:
德克索鲁比辛 (doxorubicin) 是一种药物.微型气泡是一种微型气泡.脉冲长度 脉冲长度 脉冲长度脉冲的重复频率是脉冲的重复频率.瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion 瘤 perfusion超声波超声波是指超声波的使用.更多相关视频
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