鼻腔NUT癌:一个连续的病例系列和系统审查
Uma Ramesh1,2, Kevin J Contrera1, Nasim Shakibai1
1Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Head & neck
|October 19, 2023
概括
鼻腔NUT癌的生存率很差,平均为15个月. 大鼻瘤和较低的阶段改善了结果,诱导化疗可能对这种罕见的癌症有益.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 癌症研究 癌症研究
背景情况:
- 鼻腔NUT癌是一种极其罕见且致命的恶性瘤.
- 关于这种侵袭性癌症的科学文献有限.
研究的目的:
- 为了评估鼻NUT癌症患者的生存结果.
- 为了确定影响生存的预后因素.
- 审查有关这种罕见恶性瘤的现有文献.
主要方法:
- 一个从2010年到2022年在一个机构治疗的鼻腔NUT癌症患者的病例系列.
- 评估整体存活率 (OS) 和疾病特异性存活率 (DSS).
- 系统的文献审查,以补充案例系列的发现.
主要成果:
- 在12名患者的中位数OS和DSS为14.6个月,平均随访时间为1.5年.
- 大鼻瘤与显著更高的生存概率相关 (HR:0.094,p=0.011).
- 更高的疾病阶段 (IVb-c) 与更糟糕的生存状况相关 (p=0.05). 三名没有疾病迹象的活着患者接受了诱导化疗.
结论:
- 鼻腔NUT癌的中位生存期大约为15个月.
- 瘤位置 (大鼻) 和较低的疾病阶段与改善的生存率有关.
- 诱导化疗可能为患有鼻腔NUT癌的患者提供生存益处.
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