埃斯特醇添加到多斯皮雷诺的好处是用于避孕
Jean Michel Foidart1,2, Kristina Gemzell-Danielsson3, Ali Kubba4
1Department of Obstetrics and Gynecology, University of Liège, Liège, Belgium (Prof Foidart and Prof Gaspard).
AJOG global reports
|October 19, 2023
概括
两种新的drospirenone-based避孕药,包括与estetrol的组合,提供有效的避孕. 雌二醇组合提供了可预测的出血形状和对血液静止的最小影响,增强了避孕选择.
科学领域:
- 药理学和生殖健康
- 避孕药的发展与发展
- 内分泌学 在内分泌学.
背景情况:
- 乙inylestradiol和drospirenone联合口服避孕药已经可用超过20年.
- 德罗斯皮伦具有抗矿物质皮质和抗雄激素的特性.
- 新配方包括一个仅含孕激素的药丸 (4毫克多司匹伦) 和一种联合口服避孕药 (15毫克埃斯特/3毫克多司匹伦).
研究的目的:
- 评估含有多斯皮伦的新型避孕药的疗效和出血概况.
- 为了比较单独使用多司匹伦的血液静止和代谢效应与以斯特醇-多司匹伦组合.
- 评估这些新型口服避孕药的整体安全性和耐受性.
主要方法:
- 进行了3期临床研究,以确定使用珍珠指数的避孕疗效.
- 血流模式,包括计划和非计划的出血,都被仔细记录下来.
- 对两种配方的不良事件,代谢参数和静血标志物进行了评估.
主要成果:
- 对于单独的多司匹伦的珍珠指数是4.0 (美国) 和0.93 (欧盟);对于乙醇-多司匹伦,它是2.65 (美国) 和0.44 (欧盟).
- 单独使用德罗斯皮伦显示出高的非计划性和低的计划性出血率.
- 埃斯特罗尔-德罗斯皮雷诺结合剂显示出可预测的出血形状,最少的非计划出血 (斑点出血).
结论:
- 新的仅用多斯皮伦和埃斯特罗尔-多斯皮伦的避孕药是市场上有价值的新增.
- 埃斯特罗尔-德罗斯皮雷诺组合提供了更好的避孕疗效和更常规的出血模式.
- 埃斯特醇独特的雌激素受体活性对肝脏,乳腺和血液静止的影响很小,对骨和心血管健康有好处.
关键词:
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