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针对COVID-19的不同口水的有效性:系统性审查和网络元分析
Luca Sbricoli1, Lucia Schiavon1, Giulia Brunello1,2
1Department of Neurosciences, School of Dentistry, University of Padua, 35128 Padua, Italy.
The Japanese dental science review
|October 19, 2023
概括
消毒口水在减少唾液中的SARS-CoV-2病毒载量方面表现有前途,无论是在临床上还是体外. 需要进一步的大规模试验来确认有效使用的最佳协议.
科学领域:
- 口腔卫生 口腔卫生
- 传染病控制 传染病控制
- 病毒学 病毒学
背景情况:
- 导致COVID-19的SARS-CoV-2病毒可能存在于口腔中.
- 消毒口水通常用于口腔卫生,并且可能具有抗病毒性质.
研究的目的:
- 系统评估消毒口水在减少SARS-CoV-2病毒载量的有效性.
- 评估临床和体外证据,以评估口水对SARS-CoV-2的疗效.
主要方法:
- 在MEDLINE,Scopus和Cochrane数据库中进行了系统的文献搜索.
- 包括的研究是2019年至2023年6月期间发表的前性临床试验和体外实验.
- 数据被描述性地分析,对临床试验进行了网络元分析.
主要成果:
- 35项研究 (14项临床,21项实验室) 符合纳入标准,其中一些研究具有高偏差风险.
- 常见的测试剂包括赫西丁,波维-,过氧化和化.
- 描述性分析表明,口水可降低唾液病毒载量;然而,网络元分析显示高异质性. 只有0.20%的赫西丁在冲洗后的唾液中显示出显著的Ct增加.
结论:
- 目前的临床和体外试验数据表明,常用的消毒口水具有针对SARS-CoV-2的抗病毒功效.
- 需要进行更大规模,更精心设计的临床试验,以建立明确的证据和最佳使用方案.
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