相关实验视频
Updated: Aug 8, 2026

07:44
Design and Synthesis of a Reconfigurable DNA Accordion Rack
Published on: August 15, 2018
概括
DNA可以采用不同的结构,如A,B和Z形式. 降低水的活动驱动转换到A-DNA或Z-DNA由于更经济的水合,解释结构变化.
科学领域:
- 分子生物学分子生物学
- 结构生物学 结构生物学
- 生物化学 生物化学
背景情况:
- DNA存在于多种双螺旋形状,包括右手的A-DNA和B-DNA,以及左手的Z-DNA.
- 在高水活动条件下,B-DNA构造是普遍存在的.
研究的目的:
- 研究不同形状 (A,B和Z) 之间的DNA结构转换.
- 阐明驱动这些形状变化的潜在分子机制.
主要方法:
- 对寡核酸的晶体结构的分析.
- 检查不同DNA结构中的酸盐间距离和水分子相互作用.
主要成果:
- 在B-DNA中,相邻的酸盐组至少相隔6.6 Å,并且单独水.
- 在A-DNA和Z-DNA中,酸盐组相距较近 (分别为5.3 Å和4.4 Å),并由水分子组成桥梁.
- 在A-DNA和Z-DNA中这些更近的距离表明更经济的水合.
结论:
- 在DNA形状之间观察到的水化经济差异被认为是B-DNA到A-DNA和B-DNA到Z-DNA转换的主要驱动因素.
- 与B-DNA相比,A-和Z-DNA的经济水分是这些重大结构变化的基础.
相关概念视频
Nucleic acids
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
The DNA Helix
Overview
Nucleic Acids
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
DNA as a Genetic Template
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
The DNA Helix
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
Nucleic Acid Structure
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
DNA Structure
DNA has a double-helix structure. The...

