在上部内镜检查之前,西美西康的最佳时间:多中心,单盲,随机对照试验
I N Beaufort1,2, R E Verbeek3, J H Bosman3
1Department of Gastroenterology and Hepatology, Sint Antonius Hospital, Nieuwegein, the Netherlands.
早期服用西美西康,一次性或分剂量,可以在上部内镜检查期间改善粘膜的可见性. 这种增强的可见性有助于更好地可视化胃肠道.
科学领域:
- 胃肠病学 胃肠病学
- 内镜手术 进行内镜手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 西梅西康因其抗泡特性而被用作上部内镜前期治疗.
- 优化粘膜可见性对于准确的内镜诊断和干预至关重要.
研究的目的:
- 评估在上部内镜检查过程中西美西康施用时间对粘膜可见性的影响.
- 为了比较早期,晚期和分剂量西美西康治疗方案,以了解它们对内镜可视化的影响.
主要方法:
- 一项多中心,随机,内镜盲目的研究,涉及386名接受上部内镜检查的患者.
- 患者在不同的时间接受了simethicone:在20-30分钟前 (早期),在0-10分钟前 (晚期) 或分剂方案.
- 粘膜可见性被独立的内镜师在预定义的胃肠道位置客观地得分.
主要成果:
- 分剂组与晚期组相比,显示出明显更好的全粘膜可见性 (TMV) (61%对42%).
- 早期服用 (单剂或分剂) 导致粘膜可见度更高,特别是在胃部.
- 在55% (早期),42% (晚期) 和61% (分剂量) 的患者中实现了适当的TMV.
结论:
- 早期使用西美西康 (simethicone),无论是单剂或分剂,都能优化上部内镜的粘膜可见性.
- 赛美西康的时间是提高内镜手术期间可视化的关键因素.
- 建议分剂或早期单剂量西美西康用于改善内镜成像.
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