在患有PCOS的女性中,甲状腺功能障碍和高甲状腺血的患病率
Kim van der Ham1, Karlijn J Stekelenburg1, Yvonne V Louwers1
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus University Medical Centre, Rotterdam, Netherlands.
Frontiers in endocrinology
|October 19, 2023
概括
与对照组相比,患有多囊性卵巢综合征 (PCOS) 的女性没有甲状腺功能障碍或高甲状腺素血的更高患病率. 在这项研究中,甲状腺疾病和高甲状腺血症的发病率在各组之间是相似的.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 内部医学 内部医学
背景情况:
- 多囊卵巢综合征 (PCOS) 是最常见的内分泌疾病,导致排卵功能障碍.
- 结核复合综合症与孕激素水平降低有关,可能增加自身免疫性疾病的风险.
- 需要进一步调查PCOS,甲状腺功能障碍和高甲状腺素血症之间的关系.
研究的目的:
- 为了调查患有PCOS的女性甲状腺功能障碍和高甲状腺血的患病率.
- 为了比较PCOS表型之间的这些患病率.
- 将PCOS患者与对照组进行比较.
主要方法:
- 对1429名患有PCOS的女性和299名对照女性进行了回顾性横截面研究.
- 测量了TSH,FT4和TPOab的血清水平.
- 估计甲状腺疾病和高甲状腺血症的患病率.
主要成果:
- 在PCOS和对照组之间,甲状腺疾病 (甲状腺功能低下,甲状腺功能过高) 的患病率没有显著差异.
- 类似的TSH和FT4水平,在PCOS中FT4在正常范围内略高.
- 在两组中,阳性TPOab和高甲状腺素血的患病率相似.
结论:
- 与对照组相比,患有PCOS的女性没有出现甲状腺功能障碍的更高发病率.
- 患有PCOS和不患PCOS的女性中,高血的患病率相似.
- 在PCOS表型B中,亚临床甲状腺功能障碍更为普遍,需要进一步研究.
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