通过内分泌干扰剂调节胎盘生长,发育和生殖功能
Sanjay Basak1, Saikanth Varma1, Asim K Duttaroy2
1Molecular Biology Division, ICMR-National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
Frontiers in endocrinology
|October 19, 2023
概括
母亲接触双和酸盐等内分泌干扰剂可能会损害胎儿发育和后代的健康. 这些化学物质干扰关键的荷尔蒙平衡,影响胎盘功能和长期的代谢和生殖结果.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 发展性毒理学 发展性毒理学
背景情况:
- 孕妇内分泌平衡对于怀孕成功至关重要,涉及雌激素和胰岛素等激素.
- 干扰内分泌的化学物质 (EDC),如双 (BPs) 和酸盐,无处不在,对代谢和生殖健康构成风险.
- 胎儿特别容易受到EDC的影响,因为他们对排毒能力有限,导致发育编程.
研究的目的:
- 审查对由雌激素模仿化学物质引起的孕产妇内分泌调节的最新研究.
- 检查EDC暴露对胎盘发育,胎儿生长以及后代代谢和生殖功能的影响.
- 为了突出怀孕期间EDC暴露的亚细胞和跨代影响.
主要方法:
- 关于母亲内分泌干扰和EDC暴露的研究的文献综述.
- 对双和酸盐对雌激素受体和内分泌通路的影响的研究分析.
- 检查关于胎盘发育,营养物质运输和表观遗传变化的数据.
主要成果:
- 产前暴露于BP和酸盐可能会损害母亲的生殖器官和胎盘发育,影响血管化和生长因子表达.
- EDCs改变体下垂体反应和营养物质运输体表达,导致胎盘缺陷和表观遗传修饰.
- 母亲接触EDC可以为不良的代谢,内分泌和生殖结果编程后代.
结论:
- 产前暴露于雌激素EDC显著影响母亲内分泌平衡和胎盘发育.
- 这些暴露可能会对后代健康产生持久的有害影响,包括代谢和生殖功能障碍.
- 了解这些影响对于减轻怀孕期间与环境内分泌干扰物相关的风险至关重要.
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