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在A/J小鼠中,arubigins/聚合物黑茶多 (PBPs) 不能预防[a]pyrene (B[a]P) 诱导的肺瘤

Zaid M Shaikh^1,2, Nirav Bhatia¹, Prasad Aradhye¹

¹Mahimkar Lab, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre Navi Mumbai 410210, Maharashtra, India.

American journal of translational research

|October 19, 2023

概括

氨基基/聚合物黑茶多 (PBPs) 没有预防小鼠的[a]皮林 (B[a]P) 诱导的肺癌. 需要进一步的研究,以了解化学预防剂对复杂致癌物质组合的疗效.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
癌症研究癌症研究

背景情况:

乌鲁比金/聚合物黑茶多 (PBP) 显示对结合的烟草烟雾致癌物具有化学预防作用.
甲烯 (B[a]P) 是PM2.5和烟草烟雾中普遍存在的致癌物,尚未与PBPs作为单一剂进行研究.
了解B[a]P的致癌性对于环境和公共健康至关重要.

研究的目的:

评估PBPs对B[a]P诱导的肺癌发生的化学预防疗效.
研究PBP作用或不作用背后的分子机制.
评估PBPs对异生物代谢,DNA损伤,炎症,亡和扩散的影响.

主要方法:

在B[a]P暴露之前,A/J小鼠接受了三剂PBPs (1.5,5,10%) 的预处理.
瘤发病率和多重性在早期和晚期时间点被评估.
西方涂抹用于分析与致癌途径相关的分子生物标志物.

主要成果:

在B[a]P诱导的肺癌发生过程中,PBP并没有降低瘤发生率或多重性.
在早期时间点中,没有观察到分子标记物的显著变化.
这些发现与之前关于PBP疗效的观察结果一致.

结论:

化学预防剂需要对各种致癌物质组合和方案进行测试.
致癌与化学预防疗效之间的复杂相互作用需要进一步阐明.
这项研究为未来临床试验的考虑提供了数据.

关键词:

在A/J小鼠中.在CYP1A1/NQO1中.他们的arubiginsins.甲烯 (Benzo[a]pyrene) 是一种甲的化合物.化学预防化学预防在实验性肺癌中.

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