用免疫复合体接种疫苗可以调节针对HIV-1病毒的功能性抗体的产生
Catarina E Hioe1,2, Xiaomei Liu1, Andrew N Banin1
1Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Frontiers in immunology
|October 19, 2023
概括
开发有效的HIV-1疫苗仍然是一个挑战. 这项研究发现,DNA疫苗与特定蛋白质疫苗相结合,在子中引起了对HIV-1的中和抗体,免疫复合体表现出调节活性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 中和抗体 (Abs) 对预防病毒感染至关重要,但很难产生广泛有效的Abs对抗各种HIV-1菌株.
- 艾滋病毒-1包裹 (Env) 的V1V2顶部是中和Abs的关键目标.
研究的目的:
- 为了评估旨在诱导ABS的疫苗,针对HIV-1 Env.的V1V2顶部的中和表位.
- 评估免疫复合体 (ICs) 对疫苗诱导的免疫反应的影响.
主要方法:
- 子被免疫使用编码V1V2域的DNA疫苗 (V1V2-2J9C) 或蛋白质疫苗 (UFO-BG.ΔV3或V1V2-2J9C).
- 一些蛋白质疫苗作为免疫复合物用V1V2特异性单克隆抗体 (mAb) 2158.8进行了注射.
- 分析了幽默性免疫反应,中和活性和Ab依赖细胞化 (ADCP).
主要成果:
- 用DNA和UFO-BG.ΔV3蛋白 (未复杂或复杂) 进行疫苗接种诱导Env和V1V2结合的Abs.
- DNA/UFO-BG.ΔV3疫苗引起了对某些异质HIV-1分离物的中和ABS,尽管标位较低.
- 具有UFO-BG.ΔV3的免疫复合体显示出更高的中和和ADCP的趋势,但没有中和异质病毒.
结论:
- 结合V1V2-2J9CDNA疫苗和UFO-BG.ΔV3蛋白质疫苗,可以在子中诱导同源和异源的中和活性.
- 与mAb 2158复合的UFO-BG.ΔV3的传递调节了中和和ADCP活动的诱导.
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