PSGL-1:一种新的免疫检查点,在阻塞性睡眠呼吸暂停中驱动T细胞功能障碍
Elena Díaz-García1,2, Aldara García-Sánchez1,3, Enrique Alfaro1,2
1Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Madrid, Spain.
Frontiers in immunology
|October 19, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 与癌症风险增加有关. 在OSA患者中,P-选择因糖蛋白-1 (PSGL-1) 可能起到免疫检查点的作用,损害T细胞功能和免疫监测.
科学领域:
- 免疫学 免疫学 免疫学
- 睡眠医学 睡眠医学
- 在瘤学瘤学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与更高的癌症发病率有关,但潜在的分子机制尚不清楚.
- 粘附受体P-选择因糖蛋白-1 (PSGL-1) 已成为癌症治疗相关的潜在免疫检查点.
研究的目的:
- 研究PSGL-1及其配体 (VISTA,SIGLEC-5) 在OSA患者中的作用.
- 探索间歇性缺氧 (IH) 对OSA中PSGL-1表达和T细胞功能的影响.
主要方法:
- 在OSA患者和对照组的白细胞中评估PSGL-1和配体表达,使用体外和体外模型.
- 评估了IH对PSGL-1表达和T细胞功能的影响.
主要成果:
- 在严重的OSA患者的T淋巴细胞中,PSGL-1表达被上调,与间歇性缺氧有关.
- PSGL-1 证明了对T细胞增殖的抑制作用.
- 在OSA患者的单细胞中,SIGLEC-5的表达增加,这表明IH的调节作用.
结论:
- PSGL-1 可能起到免疫检查点的作用,有助于T细胞在OSA中的功能障碍.
- 这种功能障碍破坏了免疫监测,可能解释了OSA患者癌症发病率和攻击性增加.
关键词:
在PSGL-1中,它是PSGL-1.在SIGLEC-5中,这些T细胞是T细胞.在视野中看到的.免疫监测监测是指免疫系统的监测.免疫检查点 免疫检查点间歇性缺氧 间歇性缺氧睡眠呼吸暂停 (Sleep Apnea) 是一个更多相关视频
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
476
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
5.4K
相关概念视频
01:21Sleep Apnea
164
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
164
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:24Sleep-Wake Cycles
1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K