对于研究COVID-19神经疾病的临床前模型的新兴景观
Jason Li1, Jing Wang2, Hu Wang3
1Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
ACS pharmacology & translational science
|October 19, 2023
概括
临床前模型对于了解COVID-19的神经效应至关重要. 本综述涵盖了体外,体内和技术模型的进步,以研究SARS-CoV-2神经病理学和开发治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 病毒学 病毒学
- 病理生理学 病理生理学
背景情况:
- 冠状病毒疾病2019 (COVID-19),由SARS-CoV-2引起,主要影响呼吸系统,但越来越多地与神经症状有关.
- 由于在量化人类临床症状和将其与死后和动物模型发现相关联方面存在挑战,因此对COVID-19神经病理学的精确机制尚不清楚.
- 迫切需要强大的临床前实验模型来研究COVID-19的神经表现.
研究的目的:
- 审查研究COVID-19的神经影响的临床前模型的最新进展.
- 讨论了解SARS-CoV-2神经病理生理学的各种模型的贡献,进展和局限性.
- 探索这些模型在开发COVID-19治疗药物,疫苗和抗病毒药物的实用性.
主要方法:
- 实验室模型的审查 (初级细胞培养,干细胞衍生的神经元,器官).
- 对体内模型 (动物,非人类灵长类动物) 的审查.
- 讨论应用于COVID-19研究的新兴技术 (3D生物打印,AI,多种经济学).
主要成果:
- 临床前模型提供了多种方法来研究SARS-CoV-2与神经系统的相互作用.
- 干细胞技术和器官的进步提供了与人类相关的体外系统.
- 动物模型和先进技术有助于了解疾病机制和测试干预措施.
结论:
- 临床前模型对于阐明COVID-19神经病理学和指导临床管理至关重要.
- 这些模型对于开发和选潜在的治疗方法至关重要,包括抗病毒药物和疫苗.
- 未来的研究应该利用使用这些多样化的模型的综合方法来解决COVID-19神经学的剩余知识差距.
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