相关实验视频

Updated: Jul 12, 2025

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

在晚期帕金森病中长期强化脊髓刺激:在安慰剂控制的评估中,刺激没有影响

Rafael Bernhart Carra¹, Tamine Teixeira da Costa Capato¹, Janaina Reis Menezes¹

¹Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.

Clinical parkinsonism & related disorders

|October 19, 2023

概括

这项研究发现,慢性脊髓刺激 (SCS) 在四名帕金森病 (PD) 患者中没有显著改善症状. 目前关于SCS在PD中有效性的证据仍然有限.

科学领域:

神经科学是一个神经科学.
神经学神经学
医疗器械医疗器械

背景情况:

帕金森病 (PD) 是一种进展性神经退行性疾病.
脊髓刺激 (SCS) 是一种用于管理PD症状的研究疗法.
有限的可靠的临床数据存在于SCS在PD的疗效.

研究的目的:

为了评估慢性脊髓刺激 (SCS) 在患有帕金森病 (PD) 的患者中的有效性.
评估低值和高值刺激参数.
确定SCS对PD症状管理的临床意义.

主要方法:

一个双盲的交叉评估,使用子值SCS.
一个使用常规超值SCS的开放标签评估.
涉及四名被诊断患有帕金森病的患者.

主要成果:

无论是下值还是上值的SCS都没有显示出PD症状的统计学上显著改善.
在测试的刺激参数中没有观察到明显的临床益处.
该研究对这一队列的SCS疗效产生了负面结果.

结论:

慢性脊髓刺激缺乏强有力的临床证据来治疗帕金森病.
需要进一步的研究来澄清SCS在PD管理中的作用,如果有的话.
目前的研究结果表明,SCS目前不是PD的可靠有效干预措施.

关键词:

结了人的步态.帕金森氏症帕金森氏症脊髓刺激脊髓刺激

更多相关视频

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Published on: October 7, 2017

相关概念视频

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...