相关实验视频

Updated: Jul 12, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

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RAG基因组变异通过特定的基于结构的酶失调机制引起自身免疫性疾病

Neshatul Haque1, Tomoki Kawai2, Brian D Ratnasinghe1

  • 1Bioinformatics Research and Development Laboratory, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

iScience
|October 19, 2023
PubMed
概括

了解导致免疫缺陷的遗传变异至关重要. 这项研究模拟了人类RAG复合酶,揭示了突变如何影响功能,并预测了新的遗传变异对改善诊断的影响.

关键词:
遗传学 是一个遗传学.分子建模分子建模分子结构分子结构.

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