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儿童医学中的安非他胺:临床试验的审查.gov

Samer O Alalalmeh^1,2, Omar E Hegazi^1,2, Moyad Shahwan^1,2

¹Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.

Frontiers in pharmacology

|October 19, 2023

概括

胺类药物对儿科注意力缺陷多动性障碍 (ADHD) 具有治疗潜力. 持续的研究对于平衡好处与副作用和成等风险至关重要.

科学领域:

儿科药理学儿科药理学
临床试验分析
神经发育障碍神经发育障碍

背景情况:

由于年轻患者的脆弱性,在儿科医学中使用安非他胺是一个重大的全球问题.
了解安非他胺在儿童中的治疗应用和风险对于安全有效的治疗至关重要.

研究的目的:

分析临床试验调查安非他胺在儿童中的使用.
为了确定使用安非他命治疗的初级儿科疾病.
评估这些试验的特征和结果.

主要方法:

在2023年8月6日,使用关键字"安非他胺"对ClinicalTrials.gov进行了系统搜索.
两个独立的审稿人根据预先定义的标准对试验进行了选:安非他命焦点,完成状态,干预设计和儿科参与者.
关于目标,参与者数量,持续时间和结果的数据是从19个选定的试验中提取的.

主要成果:

在179个确定的试验中,有19个符合分析的纳入标准.
注意缺陷多动症 (ADHD) 是主要的疾病,在84.2%的试验中被研究.
大多数研究是第四阶段,使用随机分配,并在美国进行.

结论:

胺类药物对儿科ADHD具有显著的治疗潜力,但必须承认潜在的副作用和成风险.
药物基因组学可能使个性化治疗能够提高疗效并减少儿科患者的不良反应.
为了平衡安非他命治疗的益处与固有的风险,需要持续研究以优化医疗用途.

关键词:

更多关于 ADHD ADHD 的文章胺类药物和胺类药物.临床试验中的临床试验.这种依赖,是一种依赖.发育中的大脑发展中的大脑儿科医学儿科医学

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