在年轻时受到的足细胞损伤会导致过早衰老,并加剧质细胞衰老
Beatriz Maria Veloso Pereira1,2, Yuting Zeng3, Joseph C Maggiore4
1Division of Nephrology, University of Washington, Seattle, Washington, United States.
American journal of physiology. Renal physiology
|October 19, 2023
概括
年轻人受细胞损伤可以诱导细胞衰老,加速脏衰老. 这种加快的衰老导致细胞寿命和健康减少,导致病老年患者的病情恶化.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年学是指老年学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 与年龄相关的疾病,特别是蛋白尿球性疾病,不成比例地影响老年人.
- 在老年患有细胞损伤的患者中,更糟糕的结果的潜在机制尚不清楚.
- 足细胞衰老是质细胞衰老的一个关键因素.
研究的目的:
- 为了调查 podocyte 损伤是否会诱导未老化的 podocytes 的衰老.
- 确定这种诱导衰老是否会加剧 podocytes 中的衰老过程.
- 探索早期的细胞损伤诱导衰老对脏健康的长期影响.
主要方法:
- 通过使用抗体,氨酸或纯氨基核酸酸进行损伤,对初级培养的人类细胞进行了损伤.
- 使用人类器官和年轻的小鼠模型的焦点细分样硬化症 (FSGS).
- 评估了衰老标记物 (CDKN2A,CDKN2D,CDKN1A,p16,p21,SA-β-gal) 和 podocyte 特定的蛋白质.
- 对老鼠进行了长期跟踪,直到成年和中年.
主要成果:
- 在体外和器官体内受细胞损伤增加了与衰老相关的基因 (CDKN2A,CDKN2D,CDKN1A) 的表达.
- 在年轻小鼠中的实验FSGS增加了质p16,p21和SA-β-gal.
- 与对照群相比,中年老鼠具有先前的FSGS表现出较高的p16和苏丹黑色染色,较低的 podocyte 密度和增加的丸痕.
- 这些发现表明加快了衰老和减少了细胞的健康寿命.
结论:
- 年轻人受细胞损伤会导致衰老.
- 这种损伤介导的衰老加速了 podocytes 的衰老过程.
- 早期的 podocyte 损伤有助于 podocyte 寿命和健康寿命的减少,影响脏衰老.
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