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在中国Omicron疫情爆发期间,txagevimab/cilgavimab对暴露前预防的作用

Jianhua You¹, Jiaxin Tian^2,3,4, Haidi Wu¹

¹Ruijin-Hainan Hospital, Shanghai Jiao Tong University School of Medicine, Hainan, China.

Expert review of anti-infective therapy

|October 19, 2023

概括

提克萨吉维马布和西尔加维马布有效地保护高风险个人免受中国的奥米克朗感染和严重的COVID-19结果. 这项现实研究发现,在接受治疗的患者中,感染,住院和轻度不良事件的发生率较低.

科学领域:

传染性疾病传染性疾病
病毒学病毒学
公共卫生公共卫生

背景情况:

中国在高传染性Omicron变种激增的情况下,在2022年底之前优化了COVID-19政策.
在政策变化期间,关于COVID-19治疗药物的有效性和安全性的真实数据至关重要.

研究的目的:

评估中国tixagevimab和cilgavimab的实际安全性和有效性.
评估对SARS-CoV-2 Omicron变种感染,住院和严重疾病的保护.

主要方法:

一组12岁以上的参与者通过肌肉内注射接受tixagevimab/cilgavimab (150毫克每片).
数据收集包括人口统计,并发症,先前感染/接种疫苗状态,不良事件和COVID-19结果.
分析的重点是感染率,住院和严重程度.

主要成果:

在443名参与者中,168人 (37.9%) 感染了SARS-CoV-2;所有病例都轻度.
只有2名患者 (0.5%) 需要住院治疗,没有重症监护室的入院或死亡.
在0.9%的患者中报告了轻微的局部不良事件;没有发生严重的全身反应.

结论:

提克萨吉维玛/西尔加维玛在保护高风险人群免受奥米克朗感染和严重的COVID-19感染方面表现出潜力.
在现实环境中,该疗法显示出良好的安全性概况,并具有最小的不良事件.
这些发现支持在中国的Omicron浪潮期间使用 tixagevimab/cilgavimab.

关键词:

在 COVID-19 疫情中,这就是Omicron.这就是SARS-CoV-2病毒.一个单克隆抗体.一个小小的小小的小小的小小的小小的

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