走向一种可持续的基托基复合材料支架,这种支架来自Scylla serrata的基托,用于骨组织工程
Agustina Setiawati1, Kateri Tricahya1, Florentinus Dika Octa Riswanto1
1Faculty of Pharmacy, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55281, Indonesia.
Journal of biomaterials science. Polymer edition
|October 19, 2023
概括
贝废弃物提供了一种有前途的基托来源,基托是骨组织工程中的关键生物材料. 从这种酸盐制成的支架显示出良好的生物相容性和适合修复非承载性骨缺陷的性能.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 生物技术是生物技术.
背景情况:
- 骨组织工程需要具有特定孔隙性,生物相容性和机械性能的支架.
- 可生物降解的聚合物因其调节性特性和可降解性而被青用于脚手架制造.
- 模仿天然的骨细胞外基质 (ECM) 对于有效的骨再生至关重要.
研究的目的:
- 为了从 (Scylla serrata) 贝废物中分离出奇托.
- 使用奇托,酸 (HAP) 和原I (COL I) 制造一个可生物降解的支架.
- 评估脚手架的物理,机械和生物特性,用于骨组织工程应用.
主要方法:
- 酸盐是从贝废物中提取出来的.
- 脚手架是使用造和冷干燥技术制造的.
- 评估了毛孔,毛孔大小,胀率,降解率和与MG-63细胞的生物相容性.
主要成果:
- 制造的脚手架呈现出一个相互连接的多孔结构,其多孔度为51.44%,孔径为109.88微米.
- 脚手架在四周内出现了显著的胀 (超过350%) 和大约23%的降解率.
- 与MG-63骨髓瘤细胞观察到出色的生物相容性,尽管压缩强度低于承载应用的范围.
结论:
- 来自贝的奇托是一种可行的生物材料,用于制造骨组织工程支架.
- 由于其生物相容性和结构特征,开发的脚手架适用于非承载性骨缺陷.
- 这项研究强调了利用废弃的贝作为先进生物材料的可持续来源的潜力.
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