瘤有机体作为癌症研究药物查平台
Reyhaneh Mahbubi Arani1, Niloufar Yousefi1, Amir Ali Hamidieh2
1Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Current stem cell research & therapy
|October 19, 2023
概括
有机体和瘤体为药物发现和个性化癌症治疗提供先进的3D模型. 这些患者衍生器官 (PDO) 在临床试验和转化医学中显示出巨大的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 3D模型越来越多地用于药物发现,敏感性评估和毒性评估.
- 有机体,其有机型结构,对于桥梁基础研究和临床应用至关重要,特别是在癌症.
- 患者衍生器官 (PDO) 尽管存在标准化挑战,但在药物测试中被广泛采用.
研究的目的:
- 审查最近在癌症研究和药物开发中对有机体和瘤体的应用方面的进展.
- 突出器官在翻译医学和临床试验中的潜力.
- 讨论用于高通量药物查和个性化治疗开发的有机体的使用.
主要方法:
- 关于有机体和瘤体应用的最新科学文献的综述.
- 分析专注于使用3D细胞培养方法进行疾病建模的研究.
- 在药物查,敏感性评估和毒性测试中检查有机体的实用性.
主要成果:
- 器官类药物通过模仿受控细胞特征的器官复合来促进准确的药物评估.
- 患者衍生器官 (PDO) 能够对化合物进行高通量分析和个性化治疗策略.
- 有机体和瘤体在癌症研究的临床试验中表现出显著的潜力.
结论:
- 在瘤学中,有机体是推动药物发现和个性化医学的强大工具.
- 在翻译医学中,有机体的应用正在扩大,有望改善患者的治疗结果.
- 尽管在标准化方面存在挑战,但有机体在临床前药物测试和临床试验应用中变得不可或缺.
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