运动动作在运动和背部前运动皮层中空间组织
Nicholas G Chehade1,2,3,4, Omar A Gharbawie1,2,3,4,5
1Department of Neurobiology, University of Pittsburgh, Pittsburgh, United States.
eLife
|October 19, 2023
概括
行动的神经代码在前额运动区域的空间组织. 在前肢表征中,运动皮层 (M1) 和背前运动皮层 (PMd) 中存在特定的动作调节的神经元子区域.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 皮层组织 皮层组织
背景情况:
- 额头运动区域对于自愿运动控制至关重要.
- 非人类灵长类动物的运动区域表现出体型前肢表征 (运动地图).
- 对于这些地图中的特定动作的神经代码的空间组织仍然不太了解.
研究的目的:
- 调查行动的神经代码是否在前肢运动皮层 (M1) 和背前运动皮层 (PMd) 的表征中空间组织.
- 探索灵长类人皮层运动系统中的结构功能关系.
主要方法:
- 使用高分辨率的内在信号光学成像 (ISOI) 和通过皮质内微刺激进行运动映射.
- 记录了两只的皮层活动,它们执行了受指导的达到-抓取任务.
- 量化了与M1和PMd中的前肢运动图相对的任务相关活动的空间范围.
主要成果:
- 在M1和PMd中,与任务相关的活动集中在空间组织的补丁中,覆盖前肢表示的不到40%.
- 活动模式在任务条件中显示出一致性,其大小反映了前肢使用的差异.
- 在手臂与手部区域的独特时间形状表明了前肢表征中的功能专业化.
结论:
- 在M1和PMd中前肢的表示包含了由针对特定动作的神经元丰富的子区域,表明神经代码的空间组织.
- 神经活动的空间维度是前额运动区域的重要组织原则.
- 这些发现为灵长类动物运动皮层的功能架构提供了洞察力.
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