在意大利的一组石棉工人队伍中,特定原因死亡率
Daniela Ferrante1, Alessia Angelini2, Fabiano Barbiero3
1Department of Translational Medicine, Università del Piemonte Orientale and CPO Piemonte, Novara, Italy.
American journal of industrial medicine
|October 19, 2023
概括
接触石棉显著增加了癌症的风险,特别是在胸腔和腹腔瘤. 随着时间的推移,从第一次接触以来,肺部癌症的风险会稳定下来,而腹腔癌的风险会持续上升,这与腹腔癌不同.
科学领域:
- 职业健康 职业健康 职业健康
- 流行病学 流行病学
- 环境健康 环境健康
背景情况:
- 石棉是已知的人类致癌物.
- 接触石棉与恶性间皮瘤,肺癌,喉癌和卵巢癌有关.
研究的目的:
- 调查曾接触过石棉的意大利工人的癌症风险.
- 分析基于暴露时间和第一次暴露后的时间 (TSFE) 的死亡率模式.
主要方法:
- 来自意大利52个石棉队伍的数据汇总,更新到2018年的死亡率跟踪.
- 计算主要死亡原因的标准化死亡率 (SMR).
- 分析了考虑到暴露时间和TSFE的风险,使用区域,年龄和日历期参考率.
主要成果:
- 增加了男性和女性的整体死亡率.
- 对所有恶性瘤,多发性和腹性恶性瘤,肺癌和卵巢癌的风险增加.
- 胸腔癌的死亡率增加了TSFE,在40年后停滞不前;腹腔癌的风险在整个观察期内增加.
结论:
- 斑瘤的风险与潜伏期相关,并且似乎随着长期的TSFE而减少,这表明石棉清除.
- 在整个观察时间内,腹膜瘤风险呈现连续增加.
- 这些发现强调了与石棉暴露相关的持续和多样化的癌症风险.
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