与健康的对照组相比,甲状腺功能下降的女性的氧化压力持续较高
Kamilla R Riis1,2, Camilla B Larsen1,2, Bjarke R Medici3
1Department of Endocrinology, Odense University Hospital, Odense, Denmark.
European thyroid journal
|October 19, 2023
概括
甲状腺功能低下症在治疗后不会显著改变氧化应激生物标志物8-oxo-7,8-dihydroguanosine (8-oxoGuo) 和8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG). 然而,甲状腺功能低下患者与健康人相比,这些标记物的水平更高.
科学领域:
- 内分泌学 在内分泌学.
- 生物化学 生物化学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 怀疑甲状腺功能低下与增加的氧化应激相关.
- 尿中的8-oxo-7,8-dihydroguanosine (8-oxoGuo) 和8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) 分别是RNA和DNA氧化的生物标志物.
- 这些生物标志物在甲状腺疾病患者中尚未得到充分研究.
研究的目的:
- 在新诊断为甲状腺功能低下症的妇女中检查尿液中的8-oxoGuo和8-oxodG水平.
- 为了比较这些氧化应激生物标志物在治疗前和治疗后的levothyroxine.
- 为了比较euthyroid患者与健康对照者的生物标志物水平.
主要方法:
- 研究了45名丹麦妇女新诊断的甲状腺功能低下症.
- 测量尿液中的8-oxoGuo和8-oxodG分泌物在治疗前和治疗后.
- 患者生物标志物水平与18名健康对照人进行了比较.
主要成果:
- 在甲状腺功能低下患者中,Levothyroxine治疗没有显著改变8-oxoGuo或8-oxodG水平.
- 基线自由甲状腺素水平与这两种生物标志物正相关.
- 与对照组相比,优甲状腺患者的8-oxoGuo和8-oxodG的分泌量显著增加.
结论:
- 利沃甲氧治疗对氧化应激生物标志物8-oxoGuo和8-oxodG没有明显的影响.
- 甲状腺功能低下的患者,即使是甲状腺功能低下的患者,也表现出这些RNA和DNA氧化生物标志物的水平升高.
- 需要进一步的研究来了解治疗过的甲状腺功能低下症中氧化应激标志物的持续升高.
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