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解开T细胞疲:基因查与体外建模相遇

Dominic Schmid1,2, Priska Auf der Maur3,4, Marcel P Trefny5

  • 1Department of Biomedicine, Laboratory Cancer Immunology, University of Basel, Basel, Switzerland.

Cancer research
|October 19, 2023
PubMed
概括

T细胞耗尽限制了免疫疗法的有效性. 一个新的体外模型和CRISPR查确定了BHLHE40作为T细胞耗尽进展的关键,提供了新的治疗点.

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Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...