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前列腺年龄差距:为前列腺癌检测而使用MRI替代衰老标志物

Alvaro Fernandez-Quilez^1,2,3, Tobias Nordström^3,4, Fredrik Jäderling^5,6

¹Department of Computer Science and Electrical Engineering, University of Stavanger, Stavanger, Norway.

Journal of magnetic resonance imaging : JMRI

|October 19, 2023

概括

一种新的前列腺磁共振成像 (MRI) 生物标志物,前列腺年龄差距 (PAG),在识别临床上显著的前列腺癌 (csPC) 风险方面表现有前途. 这种衰老生物标志物在检测CSPC时可能会超过传统的风险因素.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
人工智能的人工智能

背景情况:

衰老是前列腺癌 (PC) 的主要危险因素.
前列腺MRI可以揭示与年龄相关的变化,但缺乏已确定的衰老生物标志物.
探索新的成像生物标志物对于PC风险评估至关重要.

研究的目的:

用前列腺MRI开发一个衰老的生物标志物.
评估这种生物标志物与临床显著PC (csPC) 风险之间的关联.

主要方法:

这是一项追溯性研究,涉及468名经过活检的男性.
在前列腺MRI切片上训练了一种深度学习 (DL) 模型,以估计患者的年龄.
前列腺年龄差距 (PAG) 被计算为估计年龄减去时间年龄.
多变量逻辑回归分析了PAG和csPC风险之间的关系.

主要成果:

DL模型通过前列腺MRI估计了患者的年龄.
PAG与增加cspc几率 (OR=3.78) 有显著的关联.
与PI-RADS得分相比,PAG在csPC和非csPC之间进行了更好的歧视 (AUC=0.981).

结论:

前列腺年龄差距 (PAG) 显示出作为cspc风险的独立生物标志物的潜力.
PAG可能会改善前列腺癌风险分层.
这种基于MRI的新型衰老生物标志物需要进一步调查.

关键词:

这就是为什么MRI是MRI.年龄的年龄年龄的年龄.深度学习是一种深度学习.前列腺癌是前列腺癌.有关风险因素的风险因素.查检查查检查查检查查检查

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