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Updated: Jul 12, 2025

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
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Published on: March 10, 2020

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由压素2型受体的β-阿雷斯依赖和独立的内体G蛋白激活

Carole Daly1, Akim Abdul Guseinov2, Hyunggu Hahn3,4

  • 1Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.

eLife
|October 19, 2023
PubMed
概括

血管压素2型受体 (V2R) 通过与G蛋白和β-停滞蛋白相互作用,在内部化过程中维持信号传递. 这项研究揭示了V2R也在内分泌体中激活Gαq/11,挑战了当前G蛋白结合受体信号传递模型.

关键词:
它们是G蛋白质.在被逮捕后被捕.细胞生物学 细胞生物学内部体内信号传递.人类 人类 人类 人类 人类 人类 人类一个巨大的复合体.压素类型2受体受体

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